Longevity
Cellular age, rewound
A pineal peptide used to support telomerase activity, sleep cycles and healthy aging.
Ships as a freeze-dried powder. Need water to mix it? Add Reconstitution Solution.
The science
Evidence level
1/5
Preclinical
Telomere, circadian and lifespan findings come from cell and animal research; human longevity outcomes have not been tested in controlled trials.
12.3%3
longer maximum lifespan in aging mice versus controls
17.1%3
fewer chromosome aberrations in bone-marrow cells of treated mice
Telomerase2
switched on in human cells, with telomeres lengthened
Mechanism of action
Targets & pathways
Added to telomerase-negative human fetal fibroblasts, Epitalon induced the enzyme’s catalytic subunit, switched on telomerase activity and lengthened telomeres2.
In aging female mice, long-term Epitalon reduced the frequency of chromosome aberrations in bone-marrow cells by 17.1%3.
In senescent monkeys it significantly stimulated evening melatonin synthesis and normalized the daily rhythm of cortisol secretion4.
Treated mice showed a 13.3% longer lifespan among the last 10% of survivors and a 12.3% longer maximum lifespan than controls3.
What the research shows
Human somatic cells in culture showed telomerase induction and measurable telomere elongation.
Aging mice treated with Epitalon reached a 12.3% longer maximum lifespan, with fewer chromosome aberrations.
Senescent monkeys showed restored evening melatonin synthesis and a normalized cortisol rhythm.
A 2025 review summarizes 25 years of cell, animal and computational studies pointing to geroprotective and neuroendocrine effects.
Reviews the AEDG peptide’s pineal origin and predominantly laboratory and animal evidence, distinguishing its development from a mixed extract.
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
International journal of molecular sciences · 2025
PubMed ↗ (opens in a new tab)A publisher correction updating figures in the 2025 cell-line telomere study.
Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Biogerontology · 2025
PubMed ↗ (opens in a new tab)Mean mouse lifespan was unchanged, while the last tenth of survivors lived 13.3% longer and maximum lifespan increased 12.3%.
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
Biogerontology · 2003
PubMed ↗ (opens in a new tab)Questions
No controlled human evidence cited here establishes biological-age reversal.
No. Epitalon is a defined tetrapeptide; Epithalamin is a pineal extract with a different composition.
It refers to a late-surviving subgroup; mean lifespan was unchanged.
Epitalon research emphasizes telomeres and pineal signals. NAD+ is a metabolic coenzyme, with precursor trials that do not validate injected NAD+.
No. Telomere maintenance has context-dependent effects, including in cancer cells; a biomarker change is not automatically a health benefit.
Longevity
Longevity
Longevity