Focus & Mood
Calm, clear focus
An anxiolytic peptide used to reduce stress and sharpen focus without sedation.
Ships as a freeze-dried powder. Need water to mix it? Add Reconstitution Solution.
The science
Evidence level
3/5
Controlled human trials
Small clinical studies and mechanistic research; larger controlled trials outside Russia have not been published.
621
patients in a head-to-head comparison with the benzodiazepine medazepam
702
patients in a study of Selank added to benzodiazepine therapy
843
neurotransmission genes profiled in rat frontal cortex after Selank
Mechanism of action
Targets & pathways
Selank extends tuftsin, an immune-regulating peptide, with a stabilizing Pro-Gly-Pro tail, giving a seven-amino-acid neuroactive molecule5.
Binding studies show Selank acts as a positive allosteric modulator of GABA binding, the receptor system targeted by benzodiazepines5.
In rat hippocampal slices, Selank altered spontaneous inhibitory synaptic activity in CA1 neurons4.
What the research shows
In 62 patients with anxiety disorders, Selank’s anxiolytic effect matched medazepam, with additional anti-fatigue and stimulant effects.
Added to phenazepam, Selank brought earlier improvement and reduced sedation, memory impairment and fatigue during and after treatment.
Greater efficacy and fewer side effects improved quality of life for patients treated with Selank as an add-on.
A 70-patient comparison examined phenazepam alone versus Selank added to phenazepam.
[Optimization of the treatment of anxiety disorders with selank].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2015
PubMed ↗ (opens in a new tab)In 62 patients with anxiety disorders and neurasthenia, Selank’s anxiolytic effect matched medazepam, with added anti-fatigue and stimulant effects.
[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2008
PubMed ↗ (opens in a new tab)Rat cortical experiments examined 84 neurotransmission genes and found time-dependent expression changes.
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
Frontiers in pharmacology · 2016
PubMed ↗ (opens in a new tab)Questions
Selank research emphasizes inhibitory signalling and anxiety-related reports. Semax work emphasizes neurotrophins and neural-network observations; neither establishes a broad cognitive benefit for this vial.
The small comparator studies do not establish safe interchangeability or a withdrawal plan.
No. Small studies and laboratory mechanisms cannot guarantee an individual’s response.
Detailed design is not consistently clear from the indexed early reports; they should not be described as large modern placebo-controlled trials.
No. Exposure, formulation and safety must be evaluated for the actual prescribed route.
Focus & Mood